VLE a blessing or a curse: VLE use by HE Academic Staff

This study makes use of qualitative and quantitative methods to explore how a Virtual Learning Environment (VLE) can be supported in a Higher Education setting. Data analysis showed that holistic support strategies were capable of targeting larger groups of teachers effectively via staff development workshops and strategies. School-wide mechanisms were embedded establishing a ‘standard’ for the VLE. Once adoption of the VLE across the school had reached its peak, course teams required bespoke and specialised support. This required revisiting the (formative and summative) assessment techniques in module specifications to incorporate this use of the VLE. In conclusion, use of the VLE has levelled after the ‘peak’, individualised support is critical to maintain progression and benefit of the VLE which can be done through short-term strategies. The skill-set of those providing the support evolved from technical expertise to one that incorporates a good understanding of relative pedagogy

Mediating urban politics

Despite the turn to relational vocabularies in urban theory, most work on urban politics acknowledging the importance of media has tended to reproduce a centred image of ‘the media’ and a functionalist account of mediation. This essay suggests, by contrast, that media might be understood more phenomenologically, as those technologies embedded in the dispersed practices of urban life, and as assemblages of integrative practices (i.e. ‘the media’), both of which identify and subject to action a range of issues that are problematized as ‘urban’. Such a focus on media-in-practices is an important shift in perspective for research hoping to bring together the shared political concerns of urban and media studies, and to take advantage of the converging spatial imaginations and reconfigured understandings of mediation emerging across both fields

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/mTOR pathways on cell migration in MDA-MB-231 cells

The study of eukaryotic initiation factor 4E (eIF4E) is a key focus in cancer research due to its role in controlling the translation of tumour-associated proteins, that drive an aggressive migratory phenotype. eIF4E is a limiting component of the eIF4F complex which is a critical determinant for the translation of mRNAs. Mitogenactivated protein kinase interacting protein kinases (MNK1/2) phosphorylate eIF4E on Ser209, promoting the expression of oncogenic proteins, whereas mTORC1 phosphorylates and de-activates the eIF4E inhibitor, 4E-BP1, to release translational repression. Here we show that inhibiting these pathways simultaneously effectively slows the rate of cell migration in breast cancer cells. However, a molecular hybridisation approach using novel, cleavable dual MNK1/2 and PI3K/mTOR inhibiting hybrid agents was less effective at slowing cell migration

A guide for policy makers: on reducing road fatalities

A guide for policy makers: on reducing road fatalitie

Perceptions of the coach-athlete relationship predict the attainment of mastery achievement goals six months later : a two-wave longitudinal study among F.A. Premier League academy soccer players

All football teams that compete within the F. A. Premier League possess an academy, whose objective is to produce more and better home-grown players that are capable of playing professionally. These young players spend a large amount of time with their coach, but little is known about player’s perception of the coach-athlete relationship within F.A. Premier League Academies. The objectives of this study were to examine whether perceptions of the coach-athlete relationship changed over six months and if the coach-athlete relationship predicted self-reported goal achievement among F. A. Premier League academy players. This study included cross-sectional (n = 104) and longitudinal (n = 52) assessments, in which academy soccer players completed a measure of the coach-athlete relationship and goal achievement across either one or two time periods. The cross-sectional data were subjected to bivariate correlations, whereas the longitudinal data were analyzed using multiple regressions. Perceptions of the coach-athlete relationship remained stable over time. The coach-athlete relationship predicted the achievement of mastery goals six months later. Enhancing the quality of the coach-athlete relationship among elite adolescent athletes appears to be a suitable way of maximizing mastery achievement goals, particularly among developmental athletes who participate in team sports

Probing the anticancer action of novel ferrocene analogues of MNK inhibitors

Two novel ferrocene-containing compounds based upon a known MNK1/2 kinase (MAPK-interacting kinase) inhibitor have been synthesized. The compounds were designed to use the unique shape of ferrocene to exploit a large hydrophobic pocket in MNK1/2 that is only partially occupied by the original compound. Screening of the ferrocene analogues showed that both exhibited potent anticancer effects in several breast cancer and AML (acute myeloid leukemia) cell lines, despite a loss of MNK potency. The most potent ferrocene-based compound 5 was further analysed in vitro in MDA-MB-231 (triple negative breast cancer cells). Dose–response curves of compound 5 for 2D assay and 3D assay generated IC50 values (half maximal inhibitory concentration) of 0.55 µM and 1.25 µM, respectively

Tensor gradiometry with a diamond magnetometer

Vector magnetometry provides more information than scalar measurements for magnetic surveys utilized in space, defense, medical, geological and industrial applications. These areas would benefit from a mobile vector magnetometer that can operate in extreme conditions. Here we present a scanning fiber-coupled nitrogen vacancy (NV) center vector magnetometer. Feedback control of the microwave excitation frequency is employed to improve dynamic range and maintain sensitivity during movement of the sensor head. Tracking of the excitation frequency shifts for all four orientations of the NV center allow us to image the vector magnetic field of a damaged steel plate. We calculate the magnetic tensor gradiometry images in real time, and they allow us to detect smaller damage than is possible with vector or scalar imaging.Comment: 6 pages, 5 figure